Mechanism of Action

Heqet Therapeutics pipeline compounds efficiently target multiple pathways via the upregulation of certain non-coding RNAs. These include two factors in the Hippo pathway, the upstream inhibitory TAO kinase 1 (TAOK1) and the phospho-YAP E3 ubiquitin-ligase β-transducing repeat containing protein (β-TrCP)15,  and the actin cytoskeleton regulatory protein cofilin-216.


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Giacca, M. (2020). Cardiac regeneration after myocardial infarction: an approachable goal. Current Cardiology Reports, 22(10), 1-8.

Braga, L., Ali, H., Secco, I., & Giacca, M. (2021). Non-coding RNA therapeutics for cardiac regeneration. Cardiovascular research, 117(3), 674-693.